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PrECISE





  • PrECISE

    Personalized Engine for Cancer Integrative Study and Evaluation




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Welcome to PrECISE


The PrECISE project is a pilot project that combines hypothesis-driven strategies with data-driven analysis in a novel mathematical and computational methodology for the integration of genomic, epigenetic, transcriptomic, proteomic, and clinical data with the goal of risk-stratifying patients and suggesting personalized therapeutic interventions. We have the following specific objectives:

  • Development of a comprehensive computational methodology:
  • To integrate publicly available multi-omics datasets, well-characterized multiple-biopsies cohorts, and literature-driven knowledge powered by the Watson cognitive computer, developed at IBM.


  • Characterization of intra-tumour heterogeneity:
  • We will apply PrECISE to prostate cancer molecular cohorts where multiple biopsies have been generated from each patient.


  • Suggestion of chemotherapy drugs and targeted therapies for each patient:
  • We will investigate molecular mechanisms, identify suitable intervention points for therapy and suggest personalized therapies based on patient’s clonal signatures, and we will validate our predictions in a panel of prostatic cell lines.


  • Development of PrECISE into deployable, easy to use software tool:
  • We will integrate the developed computational modules with the Watson cognitive technology developed at IBM in a user-friendly interface and make PrECISE accessible to the clinical research community.


Welcome to PrECISE


2017

Frontiers in Metabolism - From system physiology to precision medicine (Life Sciences Symposium 2017)

24th-26th of October, 2017 in Lausanne, Switzerland

The symposium enables speakers and participants to discuss novel findings that link basic concepts emerging from the fields of cell biology, signaling, metabolomics, physiology, genetics/genomics, and aging with the pathogenesis and management of the metabolic syndrome a major medical challenge. The objective is to create an interdisciplinary environment that brings together basic scientists and clinicians with an interest in metabolomic diseases, to foster innovative ideas in this area. Partner ETH presented their work on the selection of stable biomarker signature for prediction of metabolic phenotypes.

 

17th Workshop on Network Tools and Applications for Biology (NETTAB 2017)

16th-18th of October, 2017 in Palermo, Italy

The Workshop Methods, tools and platforms for Personalized Medicine in the Big Data Era will be the 17th edition of the NETTAB Workshops series. It will be hosted by the Istituto di Calcolo e Reti ad Alte Prestazioni (ICAR-CNR) of the Italian National Research Council. Partner UKAACHEN presented their work on integrating multiple layers of information extracted from cell lines and drugs in one of the poster sessions.

 

25th Conference for Molecular Biology and the 16th European Conference on Computational Biology (ISMB/ECCB 2017)

21st-25th of July, 2017 in Prague, Czech Republic

ISMB/ECCB 2017 provide an intense multidisciplinary forum for disseminating the latest developments in bioinformatics/computational biology, fostering fresh dialogues and perspectives to learn about and shape the future of the field. One day before the conference, the PrECISE consortium met in Prague to discuss project internal, ongoing topics.

 

101st Annual Meeting of the German Society of Pathology

22nd-24th of June, 2017 in Erlangen, Germany

The DGP 2017 took place in June 2017 in the Heinrich-Lades-Halle in Erlangen and ran under the slogan "Pathology: Innovation and Cooperation". The chairman of the congress is Prof. Dr. med. Arndt Hartmann. The congress language is German, selected sessions will be held in English.

 

2016

ROCKY 2016: 14th Annual Rocky Mountain Bioinformatics Conference

08th-10th of December, 2016 in Aspen, Colorado

The fourteenth annual Rocky Mountain Bioinformatics Conference, a meeting of the International Society for Computational Biology (ISCB), took place in December 2016 in Aspen, Colorado. The Rocky series began fourteen years ago as a regional conference, and has grown into an international program with a spotlight on regional development in the computational biosciences. The presenters of the Rocky conference are scientists representing a broad spectrum of universities, industrial enterprises, government laboratories, and medical libraries from around the world. Roland Mathis of IBM, a partner of the PrECISE consortium (IBM) gave a talk there (Stratification of prostate cancer patients based on molecular interaction profiles).

 

Interview by L'Hebdo

02nd of December, 2016 Swiss/France

An interview with IBM on artificial intelligence was published on 2nd December 2016 in the Swiss French Newspaper L’Hebdo.

 

Symposium - Proteomic Applications in Oncology

07th-09th of November, 2016 in Cambridge, UK

Tiannan Guo has presented relevant research at Symposium: Proteomic Applications in Oncology in Cancer Reearch UK Cambridge Institute

 

International Conference on Systems Biology (ICSB)

16th-20th of September, 2016 in Barcelona, Spain

The Curie Institute Paris and the University Hospital Aachen are participating in this year's ICSB Conference in Barcelona. Pauline Traynard will give a hands-on tutorial during a satellite workshop covering a computer tool for modeling and simulation of genetic regulatory networks. Moreover, there will a tutorial about the tool CellNOpt developed by the Saez-Rodriguez research group. CellNOpt is intensively used by the PrECISE consortium. There has also been a poster presentation on Omnipath. Find the poster here.

 

15th European Conference on Computational Biology (ECCB 2016)

4th-7th of September, 2016 The Hague, Netherlands

IBM presented a poster at ECCB 2016

 

All SystemsX.ch Day 2016

1st of September, 2016 in Bern, Switzerland

Members of the PrECISE consortium presented three posters (Mathis et al., Manica et al., Guo et al.) at this year's systemsX.ch day in Bern. The conference, which took place at Zentrum Paul Klee, is a Swiss-wide networking and information exchange event for researchers and industrial partners involved or interested in SystemsX.ch projects.

 

European Conference on Mathematical and Theoretical Biology / SMB Annual Meeting

11th-15th of July, 2016 in Nottingham, United Kingdom

The European Conference on Mathematical and Theoretical Biology (ECMTB 2016) is the joint meeting of the European Society for Mathematical and Theoretical Biology and the Society for Mathematical Biology. The conference brought together researchers from around the world to present and learn about cutting-edge research at the interface between mathematics and the life sciences. Pauline Traynard from Institute Curie presented model-checking methods to analyse logical models, with a case study on a model of the cell cycle that is part of the generic map that is currently built in Deliverable D5.1. CI presented the PrECISE project as a part of a broader talk at ECTMB conference in Nottingham/UK

 

byteMAL

17th of June, 2016 in Aachen, Germany

Luis Tobalina and David Henriques (UKAACHEN) participated in this conference and presented the poster “An integrative Systems Biology approach to advance in the understanding and treatment of prostate cancer”. See poster.

 

American Society for Mass Spectrometry

5th - 9st of June, 2016 in San Antonio, Texas, USA

Dr. Marija Buljan (ETH) talked about protein biomarker discovery in prostate cancers. See program

 

15. Jahrestagung Sektion Molekulare Diagnostik der DGKL

1st - 3rd of June, 2016 in Tutzing, Germany

Tiannan Guo (ETH) talked about proteomics methodology and NCI60. See program

 

German Society of Pathology Annual Meeting

19th - 21st of May, 2016 in Berlin, Germany

Presentations of Peter Wild, Qing Zhong and Ulrich Wagner from UZH and Tiannan Guo and Rudolf Aebersold from ETH.

 

AACR Annual Meeting 2016

16th - 20th of April, 2016 in New Orleans, Louisiana, USA

Peter Wild (University Zurich) participated in the AACR meeting (American Association for Cancer Research). This year's theme, "Delivering Cures Through Cancer Science", reinforced the inextricable link between research and advances in patient care.

 

Analytica 2016

13th - 16th of April, 2016 in Munich, Germany

International Trade Fair for Laboratory Technology, Analyses, Biotechnology and analytica conference. Tiannan Gua (ETH) talked about proteomics methodology and NCI60.

 

Pypath Seminar

4th of April, 2016 Aachen, Germany

Introduction to Pypath, a python package to easily access signaling knowledge databases.

 

American Society for Biochemistry and Molecular Biology (ASBMB)

2nd - 6th of April, 2016 in San Diego, California, USA

ETH participated in the ASBMB and mentioned proteomics methodology, NCI60, and heterogeneity of prostate tumors. See program



July 2017

NEWSLETTER: PrECISE Newsletter Issue 3
The third newsletter gives an overview of the first project period (18 months) and provides an insight into a very interesting research topic and the technical meeting in Prague.


December 2016

NEWSLETTER: PrECISE Newsletter Issue 2
The second newsletter gives an overview of the first project year and summarizes the presentations on modelling.


August 2016

VIDEO: Introduction to the PrECISE Project
The video animation shows an overview about the main idea of the project, as well as provides first insights about ongoing tasks, analyzed data sets and relevant processing tools.


June 2016

DISSEMINATION MATERIAL: PrECISE Roll-Up
The roll up is one of our tailored dissemenation materials capable of reaching a broad audience (mainly used for fairs and project meetings).


May 2016

NEWSLETTER: PrECISE Newsletter Issue 1
The intention of this newsletter is to open a new communication channel in order to provide news on the project progress and to discuss ongoing topics relevant to PrECISE.


March 2016

PRESS RELEASE: Announcement
PrECISE Project to Construct Computational Models to Improve Prostate Cancer Treatment, Care


February 2016

DISSEMINATION MATERIAL: PrECISE Leaflet
The leaflet is one of our tailored dissemenation materials capable of reaching a broad audience (mainly used for fairs and project meetings).


January 2016

PRESS RELEASE: Announcement letter
The announcement letter was released at the project start and provides first information about the scope of PrECISE.


PrECISE is a continuously advancing project including many activities of all consortium members. PrECISE’s dissemination activities ensure the visibility and awareness of the project.

In order to keep PrECISE external project partners, stakeholders and all other interested bodies up to date, we will provide the latest news in this section. For a better overview the news are devided into:


coming soon...

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